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Regenerative medicine

Drs. Michele Anderson and Juan Carlos Zúñiga-Pflücker, senior scientists in Biological Sciences at Sunnybrook Research Institute (SRI), are making fundamental discoveries in immunology. Their focus is on T cells, a type of white blood cell that fights infection and cancer. They are studying how T cells develop, and their function in regulating the immune system. In a study published in Stem Cell Reports, the researchers showed that the HEB gene is critical to the healthy development of T cells.

They are also looking at ways of engineering T cells more efficiently, with the ultimate goal of treating people who have lost them owing to HIV, cancer treatment, or bone marrow transplant, for example.