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SRI Profiles

Nir Melamed


Division of maternal fetal medicine, department of obstetrics and gynaecology
Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room M4 140
Toronto, ON
M4N 3M5

Phone: 416-480-5217
Fax: 416-480-4164


  • M.Sc., 2002, biochemistry, Hebrew University, Israel
  • MD, 2002, Hebrew University, Israel
  • Specialist in obstetrics and gynecology, 2010, Rabin Medical Center, Israel
  • Subspecialty in maternal fetal medicine, 2014, University of Toronto, Canada

Appointments and Affiliations:

  • Associate scientist, Evaluative Clinical Sciences, DAN Women & Babies Research Program, Sunnybrook Research Institute
  • Staff physician, division of maternal fetal medicine, department of obstetrics and gynecology, Sunnybrook Health Sciences Centre
  • Associate professor, department of obstetrics and gynaecology, faculty of medicine, U of T

Research Foci:

  • Fetal origin of adult disease, fetal programming and epigenetics
  • Fetal growth restriction and placental dysfunction
  • Sonographic fetal weight estimation and prediction of fetal growth abnormalities
  • Preterm birth: prediction and late prematurity
  • Gender-based medicine

Research Summary:

There is compelling evidence that a stimulus or insult at a critical period of fetal development may have long-term effects that can predispose the fetus for disorders during adult life such as diabetes, obesity and heart disease. This phenomenon, known as fetal programming, is believed to be mediated at least in part, through epigenetic modifications during fetal life that can lead to long-lasting changes in gene expression. Dr. Melamed has been studying the epigenetic modification of fetuses conceived via assisted reproductive technologies, and is leading a study on epigenetic programming and long-term outcome of growth-restricted fetuses.

He has published several studies on the accuracy of ultrasound in the assessment of fetal growth abnormalities as well as on the role of sonographic measurement of cervical length in the prediction of preterm delivery.

He also has a special interest in the role of gender differences during fetal life including the effect of fetal gender on pregnancy complications, neonatal outcome and intrauterine growth, as well as the mechanisms underlying these gender-based differences.

Selected Publications:

See current publications list at PubMed.

  1. Melamed N, Ray JG, Hladunewich M, Cox B, Kingdom JC. Gestational hypertension and preeclampsia: are they the same disease? J Obstet Gynaecol Can. 2014 Feb;36(7):642–7.
  2. Melamed N, Ray JG, Shah PS, Berger H, Kingdom JC. Should we use customized fetal growth percentiles in urban Canada? J Obstet Gynaecol Can. 2014 Feb;36(2):164–70.
  3. Melamed N, Hiersch L, Domniz N, Maresky A, Bardin R, Yogev Y. Predictive value of cervical length in women with threatened preterm labor. Obstet Gynecol. 2013 Dec;122(6):1279–87.
  4. Melamed N, Ben-Haroush A, Meizner I, Mashiach R, Glezerman M, Yogev Y. Accuracy of sonographic weight estimation as a function of fetal sex. Ultrasound Obstet Gynecol. 2011 Jul;38(1):67–73.
  5. Melamed N, Yogev Y, Glezerman M. Effect of fetal sex on pregnancy outcome in twin pregnancies. Obstet Gynecol. 2009 Nov;114(5):1085–92.

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