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Martin Yaffe, PhD, C.M.

Senior scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room S6 57
Toronto, ON
M4N 3M5

Phone: 416-480-5715
Fax: 416-480-5714

Administrative Assistant: Jennifer Chen
Phone: 416-480-4678
Fax: 416-480-5714


  • B.Sc., 1971, honours physics, University of Manitoba, Canada
  • M.Sc., 1973, physics, University of Manitoba, Canada
  • PhD, 1978, medical biophysics, University of Toronto, Canada

Appointments and Affiliations:

Research Focus:

  • Digital imaging for medical diagnosis and management of disease

Research Summary:

Dr. Yaffe’s research is directed toward development and improvement of imaging techniques for the detection, diagnosis and treatment of cancer, with a strong focus on breast cancer. His team is also interested in methods for analyzing image patterns to predict breast cancer risk and using these as tools to study the causes of breast cancer and to help develop preventive measures.

Activities in the lab range from developing image-processing strategies for improving the quality of diagnostic images and methods of quantifying the quality of medical images, to developing and evaluating 3-D imaging (tomosynthesis) and contrast-enhanced imaging methods.

His team has established a comprehensive program in biomarker imaging research, which includes development of new techniques for 3-D pathology. These techniques will be used for validation of new in vivo imaging methods, as well as for investigating approaches to improving accuracy of pathology, and adding prognostic and predictive information in management of cancer.

Selected Publications:

See current publications list at PubMed.

  1. Clarke GM, Zubovits JT, Shaikh KA, Wang D, Dinn SR, Corwin AD, Santamaria-Pang A, Li Q, Nofech-Mozes S, Liu K, Pang Z, Filkins RJ, Yaffe MJ. A novel, automated technology for multiplex biomarker imaging and application to breast cancer. Histopathology. 2014 Jan;64(2):242–55.
  2. Falou O, Soliman H, Sadeghi-Naini A, Iradji S, Lemon-Wong S, Zubovits J, Spayne J, Dent R, Trudeau M, Boileau J-F, Wright FC, Yaffe MJ, Czarnota GJ. Diffuse optical spectroscopy evaluation of treatment response in women with locally advanced breast cancer receiving neoadjuvant chemotherapy. Transl Oncol. 2012 August;5(4):238–246.
  3. Yaffe MJ, Mainprize JG. Risk of radiation-induced breast cancer from mammography screening. Radiology. 2011;258:98–105.
  4. Hill ML, Corbin IR, Levitin RB, Cao W, Mainprize JG, Yaffe MJ, Zheng G. In vitro assessment of poly-iodinated triglyceride reconstituted low-density lipoprotein: initial steps toward CT molecular imaging. Acad Radiol. 2010 Nov;17(11):1359–65.
  5. Soliman H, Gunasekara A, Rycroft M, Zubovits J, Dent R, Spayne J, Yaffe M, Czarnota GJ. Functional imaging of neoadjuvant chemotherapy response in women with locally advanced breast cancer using diffuse optical spectroscopy. Clin Cancer Res. 2010 May 1;16(9):2605–2614.

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