Research  >  Research  >  Scientist Profiles

Scientist profiles S-Z

SRI profiles

Martin Yaffe, PhD, C.M., FRSC.

Senior scientist

Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room S6 57
Toronto, ON
M4N 3M5

Phone: 416-480-5715
Fax: 416-480-5714

Administrative assistant: Anzu Hara
Phone: 416-480-5712


  • B.Sc., 1971, honours physics, University of Manitoba, Canada
  • M.Sc., 1973, physics, University of Manitoba, Canada
  • PhD, 1978, medical biophysics, University of Toronto, Canada

Appointments, Affiliations and Honours:

  • Senior scientist, Physical Sciences, Odette Cancer Research Program, Sunnybrook Research Institute
  • Professor, departments of medical imaging and medical biophysics, U of T
  • Co-director, Imaging Research Program , Ontario Institute for Cancer Research
  • Director, Imaging Validation Core , Ontario Institute for Cancer Research
  • Chief scientific officer Centre for Imaging Technology Commercialization of Research
  • Member of the Order of Canada
  • Honorary degree recipient, Doctor of Science (honoris causa), University of Manitoba
  • Fellow, Royal Society of Canada
  • Edith Quimby Lifetime Achievement Award – American Assiation of Physicists in Medicine

Research Focus:

  • Digital imaging for medical diagnosis and management of disease

Research Summary:

Dr. Yaffe’s research is directed toward development and improvement of imaging techniques for the detection, diagnosis and treatment of cancer, with a strong focus on breast cancer. His team is also interested in methods for analyzing image patterns to predict breast cancer risk and using these as tools to study the causes of breast cancer and to help develop preventive measures.

Activities in the lab range from developing image-processing strategies for improving the quality of diagnostic images and methods of quantifying the quality of medical images, to developing and evaluating 3-D imaging (tomosynthesis) and contrast-enhanced imaging methods.

His team has established a comprehensive program in biomarker imaging research, which includes development of new techniques for 3-D pathology. These techniques will be used for validation of new in vivo imaging methods, as well as for investigating approaches to improving accuracy of pathology, and adding prognostic and predictive information in management of cancer.

Selected Publications:

See current publications list at PubMed.

  1. Alonzo-Proulx O, Mainprize JG, Harvey JA, Yaffe MJ. Investigating the feasibility of stratified breast cancer screening using a masking risk predictor. Breast Cancer Res. 2019 Aug 9;21(1):91.
  2. Yong JHE, Mainprize JG, Yaffe MJ, Ruan Y, Poirier AE, Coldman A, Nadeau C, Iragorri N, Hilsden RJ, Brenner DR. The impact of episodic screening interruption: COVID-19 and population-based cancer screening in Canada. J Med Screen. 2020 Nov 26;969141320974711.doi: 10.1177/0969141320974711. 
  3. Yaffe MJ, Seely JE, Gordon PB, Appavoo S, Kopans DB. The Randomized trial of mammography screening that was not – A cautionary tale. Journal of Medical Screening, 2021
  4. Cheung AM, Wang D, Liu K, Hope T, Murray M, Ginty F, Nofech-Mozes S, Martel AL, Yaffe MJ. Quantitative single-cell analysis of immunofluorescence protein multiplex images illustrates biomarker spatial heterogeneity within breast cancer subtypes. Breast Cancer Res. 2021 Dec 18;23(1):114. doi: 10.1186/s13058-021-01475-y. PMID: 34922607; PMCID: PMC8684264.
  5. Yaffe MJ, Mainprize JG. Overdetection of breast cancer. Published online in Current Oncology. 30 May, 2022.

Related News and Stories:

Related Links: