Holland Bone & Joint Program

Administrative assistant: Anzu Hara
Phone: 416-480-5712
Email: anzu.hara@sunnybrook.ca

Education:

• B.Sc., 2007, mechanical engineering, Queen’s University, Canada
• M.Sc., 2008, biomedical engineering, University of Oxford, U.K.
• PhD, 2012, applied physics, University of Eastern Finland, Finland

Appointments and Affiliations:

• Scientist, Physical Sciences, Holland Bone and Joint Research Program, Sunnybrook Research Institute
• Assistant professor, department of medical biophysics, University of Toronto
• Canada Research Chair in Biomedical Ultrasound, Tier 2

Research Foci:

• Therapeutic ultrasound
• Targeted drug delivery
• Monitoring and control of ultrasound therapy
  

Research Summary:

Dr. O’Reilly’s research has focused on developing systems and methods to deliver, monitor and control ultrasound therapy. In particular, she has investigated ways to map and control microbubble activity during targeted drug delivery in the brain.

Her current research interests include the investigation of cavitation-mediated therapies and the adaptation of existing ultrasound therapy techniques to new treatment targets.

Selected Publications:

See current publications list at PubMed.

1. O’Reilly MA, Jones RM, Hynynen K. Three-dimensional transcranial ultrasound imaging of microbubble clouds using a sparse hemispherical array. IEEE Trans Biomed Eng. 2014;61(4):1285–1294.
2. O'Reilly MA, Hynynen K. A super-resolution ultrasound method for brain vascular mapping. Medical Physics. 2013;40(11):110701.
3. O’Reilly MA, Hynynen K. Blood-brain barrier: Real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller. Radiology. 2012;263(1):96–106.
4. O’Reilly MA, Hynynen K. Ultrasound enhanced drug delivery to the brain and central nervous system. Int J Hyperthermia. 2012;28(4):386–396
5. O’Reilly MA, Huang Y, Hynynen K. The impact of standing wave effects on transcranial focused ultrasound disruption of the blood-brain barrier in a rat model. Phys Med Biol. 2010;55(18):5251–5267.

Related News & Stories:

• Three Sunnybrook Research Institute scientists awarded Canada Research Chairs: Drs. JoAnne McLaurin, Meaghan O’Reilly and Bojana Stefanovic recognized with country’s highest research honour (June 17, 2019)
• A cut above: Amid funding pressures, SRI scientists post stellar results (Feb. 1, 2019)
• Let’s talk (women in science): What will it take to boost participation of women in engineering and physics, where gender imbalance is notably prominent? Contributing to the conversation, for starters (SRI Magazine, 2018)
• Researchers target tough-to-treat brain diseases with focused ultrasound: Noninvasive imaging technique makes major gains in studies (SRI Magazine, 2018)
• A welcome disruption: Physicist breaches barricade in treatment of cancer in the spinal cord (July 17, 2018)
• Ultrasound research gets capital infusion: Two Sunnybrook Research Institute scientists receive federal and provincial infrastructure awards to further their work in image-guided therapeutics (May 22, 2018)
• Back to basics: Federal agency invests in SRI scientists (June 30, 2016)
• Q&A: Dr. Meaghan O'Reilly (SRI Magazine, 2016)
• Sunnybrook Research Institute presents biomedical engineering student with prestigious prize: Undergraduates compete for a chance to win cash award (Jan. 11, 2016)
• Ask a Scientist: What Is the Greatest Challenge Facing Science? (SRI Magazine, 2015)
• CV: Dr. Meaghan O'Reilly (May 22, 2015)

Related Links:

• Focused Ultrasound Group, Sunnybrook Research Institute
• SRI Centre of Excellence in Focused Ultrasound