Scientist profiles S-Z
SRI profiles
Senior scientist
Sunnybrook Health Sciences Centre
2075 Bayview Ave., Room S2 38
Toronto, ON
M4N 3M5
Administrative Assistant: Melanie Suttar
Phone: 416-480-6100 ext. 63537
Email: melanie.suttar@sunnybrook.ca
Education:
- MS, 1975, organic chemistry, Meerut University, India
- PhD, 1981, molecular biology, University of New Brunswick, Canada
Appointments and Affiliations:
- Senior scientist, Biological Sciences, Odette Cancer Research Program, Sunnybrook Research Institute
- Scientific Director of Molecular Diagnostics, Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre
- Academic Director, SRI Genomic Core, Sunnybrook Research Institute
- Professor, Laboratory Medicine and Pathobiology, University of Toronto
- Professor, Faculty of Dentistry, University of Toronto
- Lab Head, molecular profiling site for Exactis innovations personalize my treatment (PMT) program
- Member, steering committee, OCTANE (Ontario-wide Cancer TArgeted Nucleic acid Evaluation) study.
- Editor-in-chief, Cancer Genomics and Proteomics
Research Foci:
- Clinical biomarker development and validation
- Comprehensive genomic profiling for personalized medicine
- Precision oncology diagnostics
- Functional assays for molecular medicine
Research Summary:
The major focus of Dr. Seth’s research is to understand the molecular mechanisms of cancer development and progression to metastasis. His elucidation of molecular targets has resulted in numerous precision diagnostic and therapeutic applications. He has developed and used novel functional assays such as PDX mouse models to understand molecular mechanisms in cancer. Currently, he applies next generation sequencing approaches for early detection of cancer and to develop molecular therapeutic strategies that interfere with the function of key genes and proteins affecting specific cancers. Discovery of personalized targets and biomarkers is another result of his experience and expertise in comprehensive genomics profiling and molecular biology. His extensive collaborations developed over 20 years advance and support research by clinical departments at Sunnybrook Health Sciences Centre as they embrace genomic and other molecular diagnostic approaches to personalized and precise treatment. Selected current projects include microRNA signatures as tumor biomarkers predictive of prostate cancer recurrence and metastasis, characterizing markers of response to therapy in endometrial cancer, pre-operative MRI signal and mutations in colorectal cancers liver metastases.
Selected Publications:
See current publications list at PubMed.
Related News and Stories:
- Genexus System First Impressions - Thermo Fisher Scientific (Feb 24, 2020)
- Attempting to Beat Breast Cancer Armed with Collaboration and Technology
- (May 11, 2017)
- New retrospective study aims to identify mutations to better diagnose breast cancer in the future (Aug. 17, 2016)
- "Bespoke" prostate cancer treatment: Genomics and imaging tools are cracking the tough nut of prostate cancer, exposing which patients are most likely to get worse, and where tumours might be concealed (SRI Magazine, 2016)
- Tool kit: BioRad's QX200 ddPCR system: Sensitive detection and absolute quantification of target DNA or RNA molecules (May 22, 2015)
- In search of a sign: Newly identified prostate cancer genes may aid patient prognosis (June 11, 2014)
- Tool kit: Ion personal genome machine (Nexus, Spring 2014)
- On Target?: The promise and challenges of molecular therapies (SRI Magazine, 2012)
- Sunnybrook molecular biologists get funds for cancer research: Two cancer scientists at SRI have been awarded research grants from CIHR (Aug. 26, 2009)
- Letting genes point the way: Canadian Cancer Society profiles SRI senior scientist for National Cancer Awareness Week (Sept. 9, 2008)
- Spring up: Eleven SRI researchers are recognized by a quartet of funding bodies (June 3, 2008)
- Cool summer science: Student poster event fosters friendly competition and idea exchange (Sept. 17, 2007)
- The penny drops: Sunnybrook Research Institute scientists give Canadian Cancer Society leaders a glimpse of where the money goes (April 4, 2007)
- Hybrid gene targets high relapse risk in prostate cancer patients (Jan. 23, 2007)
- Spotlight on Breast Cancer Research: Aiming for a Biological Bull's-Eye (Sunnybrook Research Institute Research Report, 2002–2004)
- Spotlight on Breast Cancer Research: Trial and Success (Sunnybrook Research Institute Research Report, 2002–2004)
- Predicting tumour growth with genomics: Arun Seth and his team have developed a mouse model to predict how tumours spread, and they've received a big funding boost to do it (Jan. 1, 2005)
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